A minimalist's approach for DNA nanoconstructions

Hua Zuo; Chengde Mao

doi:10.1016/j.addr.2019.02.002

A minimalist's approach for DNA nanoconstructions

Adv Drug Deliv Rev. 2019 Jul:147:22-28. doi: 10.1016/j.addr.2019.02.002. Epub 2019 Feb 12.

Authors

Hua Zuo¹, Chengde Mao²

Affiliations

¹ Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address: zuohua@swu.edu.cn.
² Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; Chemistry Department, Purdue University, West Lafayette, IN 47907, USA. Electronic address: mao@purdue.edu.

PMID: 30769045
DOI: 10.1016/j.addr.2019.02.002

Abstract

Structural DNA nanotechnology takes DNA, a biopolymer, far beyond being the molecule that stores and transmits genetic information in biological systems. DNA has been employed as building blocks for the assembly of designed, nanoscaled, supramolecular DNA architectures for applications in biophysics, structure determination, synthetic biology, diagnostics, and drug delivery. Herein, we review a symmetric approach of tile-based DNA self-assembly. This approach allows the construction of DNA nanostructures from minimal numbers of different types of DNA strands based on sequence and structural symmetries. Some examples of the applications of this approach in siRNA delivery are discussed as well.

Keywords: DNA; DNA nanostructures; DNA nanotechnology; Self-assembly.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

DNA / chemistry*
Drug Delivery Systems
Humans
Molecular Structure
Nanostructures / chemistry*
Polymerization

Substances

DNA