XANES/EPR Evidence of the Oxidation of Nickel(II) Quinolinylpropioamide and Its Application in Csp3 -H Functionalization

Wenyan Hao; Yuchen Sha; Yi Deng; Yi Luo; Li Zeng; Shan Tang; Yue Weng; Chien-Wei Chiang; Aiwen Lei

doi:10.1002/chem.201900009

XANES/EPR Evidence of the Oxidation of Nickel(II) Quinolinylpropioamide and Its Application in Csp³ -H Functionalization

Chemistry. 2019 Apr 1;25(19):4931-4934. doi: 10.1002/chem.201900009. Epub 2019 Mar 13.

Authors

Wenyan Hao¹, Yuchen Sha², Yi Deng², Yi Luo², Li Zeng², Shan Tang², Yue Weng^{2

3}, Chien-Wei Chiang², Aiwen Lei^{1

2}

Affiliations

¹ National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P.R. China.
² College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, P.R. China.
³ National Synchrotron Radiation Research Center (NSRRC), Hsinchu Science Park, Hsinchu, Taiwan.

PMID: 30768816
DOI: 10.1002/chem.201900009

Abstract

An in situ generated oxidation species of nickel quinolinylpropioamide intermediate was produced. Characterization by X-ray absorption near edge structure (XANES) and EPR provides complementary insights into this oxidized nickel species. With aliphatic amides and isocyanides as substrates, a nickel-catalyzed facile synthesis of structurally diverse five-membered lactams could be achieved.

Keywords: Csp3−H functionalization; EPR spectroscopy; Ni catalyst; NiIII species; X-ray absorption spectroscopy.

Abstract

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