Revascularization After Intravitreal Bevacizumab and Laser Therapy of Bilateral Retinal Vascular Occlusions in Incontinentia Pigmenti (Bloch-Sulzberger Syndrome)

Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):e33-e37. doi: 10.3928/23258160-20190129-16.

Abstract

No consensus exists for the treatment of retinopathy in incontinentia pigmenti (IP). Vascular ischemia leads to tractional retinal detachments if untreated. Ultra-widefield fluorescein angiography (FA) is used to follow the vascular status of the retina. A 13-week-old female with IP presented with bilateral retinal vascular occlusions in both eyes. Ultra-widefield FA showed reperfusion after treatment with intravitreal bevacizumab (IVB) and angiography-guided laser to the avascular retina. Anti-vascular endothelial growth factor treatment reduces neovascularization and allows for growth of retinal vessels. IVB and FA-guided laser to the avascular retina is an option in IP. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e33-e37.].

Publication types

  • Case Reports

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage*
  • Bevacizumab / administration & dosage*
  • Female
  • Humans
  • Incontinentia Pigmenti / complications*
  • Infant
  • Intravitreal Injections
  • Laser Coagulation*
  • Retinal Neovascularization / drug therapy
  • Retinal Vein Occlusion / drug therapy*
  • Treatment Outcome

Substances

  • Angiogenesis Inhibitors
  • Bevacizumab