T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

Aline Silva de Miranda; Rodrigo Novaes Ferreira; Érica Leandro Marciano Vieira; Larissa Katharina Sabino Abreu; Fátima Brant; Luciene Bruno Vieira; Fabíola Mara Ribeiro; Fabiana Simão Machado; Milene Alvarenga Rachid; Antônio Lúcio Teixeira

doi:10.1016/j.jneuroim.2019.02.002

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

J Neuroimmunol. 2019 May 15:330:5-11. doi: 10.1016/j.jneuroim.2019.02.002. Epub 2019 Feb 7.

Affiliations

¹ Laboratory of Neurobiology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: mirandas.aline@gmail.com.
² Laboratory of Neurobiology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
³ Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
⁴ Laboratory of Neurobiology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
⁵ Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
⁶ Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
⁷ Department of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
⁸ Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, USA.

PMID: 30763800
DOI: 10.1016/j.jneuroim.2019.02.002

Abstract

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.

Keywords: Cerebral malaria; Chloroquine; Glutamate; MK801; Malaria; T lymphocytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dizocilpine Maleate / pharmacology
Dizocilpine Maleate / therapeutic use
Excitatory Amino Acid Antagonists / pharmacology
Excitatory Amino Acid Antagonists / therapeutic use
Female
Malaria, Cerebral / drug therapy*
Malaria, Cerebral / immunology*
Mice
Mice, Inbred C57BL
Plasmodium berghei / drug effects*
Plasmodium berghei / immunology*
T-Lymphocytes / drug effects
T-Lymphocytes / immunology*
Treatment Outcome

Substances

Excitatory Amino Acid Antagonists
Dizocilpine Maleate