RETRACTED: Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a

Qianqian Shi; Xiuying Chen; Guangli Sun; Lili Wang; Longjiang Cui

doi:10.1016/j.lfs.2019.02.021

RETRACTED: Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a

Life Sci. 2019 Mar 15:221:152-158. doi: 10.1016/j.lfs.2019.02.021. Epub 2019 Feb 11.

Authors

Qianqian Shi¹, Xiuying Chen², Guangli Sun³, Lili Wang⁴, Longjiang Cui⁵

Affiliations

¹ Department of Ophthalmology, Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China.
² Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450000, China.
³ Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
⁴ Department of Ophthalmology, People's Hospital of Zhengzhou, Zhengzhou 450000, China.
⁵ Department of Ophthalmology, Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China. Electronic address: cuilongjiang0021@sina.com.

PMID: 30763577
DOI: 10.1016/j.lfs.2019.02.021

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Given the comments of Dr Elisabeth Bik regarding this article “… the Western blot bands in all 400+ papers are all very regularly spaced and have a smooth appearance in the shape of a dumbbell or tadpole, without any of the usual smudges or stains. All bands are placed on similar looking backgrounds, suggesting they were copy/pasted from other sources, or computer generated”, the journal requested the authors to provide the raw data. However, the authors were not able to fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Diabetic retinopathy; ERK/Wnt/β-catenin; Ginsenoside Rg1; High glucose; microRNA-26a.

Publication types

Retracted Publication

MeSH terms

Apoptosis
Apoptosis Regulatory Proteins
Cell Line
Cell Survival
Ginsenosides / metabolism*
Ginsenosides / pharmacology*
Glucose / adverse effects
Glucose / metabolism
Humans
MAP Kinase Signaling System / drug effects
MicroRNAs / genetics
MicroRNAs / metabolism*
Oxidative Stress
Reactive Oxygen Species
Retinal Pigment Epithelium / drug effects
Retinal Pigments / genetics
Signal Transduction
Transcriptional Activation
Up-Regulation
Wnt Signaling Pathway / drug effects

Substances

Apoptosis Regulatory Proteins
Ginsenosides
MIRN26A microRNA, human
MicroRNAs
Reactive Oxygen Species
Retinal Pigments
Glucose
ginsenoside Rg1