Cancer invasion and metastasis is the crucial cause of death for most cancer patients. Endosome recycling of receptors for growth factors and adhesion molecules to the plasma membrane prevents them from degradation at the inside of the lysosome and recapitulates their functions, leading to major causativeness of cancer progression. Rab25 belongs to Rab-GTPase family and implicated in cancer progression in a context-dependent manner. Identified as a binding partner of Rab25, Rab coupling protein (RCP) augments cancer invasion and metastasis. In the present review, we document recent progress in Rab25- and RCP-induced cancer progression. In addition, we raise several questions should be answered for better understanding how endosome recycling by Rab25 and RCP influences cancer progression. Lastly, we update the potential therapeutic armaments to regulate Rab protein-induced endosome recycling for this deadly disease.
Keywords: Cancer progression; Endosome recycling; Rab coupling protein; Rab protein; Rab25.