Recommendations for selection of additives for stabilization of [18F]FDG

István Jószai; Márk Svidró; Norbert Pótári

doi:10.1016/j.apradiso.2019.02.001

Recommendations for selection of additives for stabilization of [¹⁸F]FDG

Appl Radiat Isot. 2019 Apr:146:78-83. doi: 10.1016/j.apradiso.2019.02.001. Epub 2019 Feb 2.

Authors

István Jószai¹, Márk Svidró², Norbert Pótári²

Affiliations

¹ Medical Imaging Department Division of Nuclear Medicine and Translational Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary. Electronic address: joszai.istvan@med.unideb.hu.
² Medical Imaging Department Division of Nuclear Medicine and Translational Imaging, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.

PMID: 30759418
DOI: 10.1016/j.apradiso.2019.02.001

Abstract

In this work, two relevant recommendations were established for selection of stabilizers for suppression of radiolysis of [¹⁸F]FDG. First, the stabilizing effect could be enhanced using selective scavengers of hydroxyl radicals (OH^·). Additionally, the initial radiochemical purity could be retained due to compounds with rate constants of their reactions with OH^· (k_OH) higher than 10⁹ M^-1 s^-1. According to these recommendations number of additives among carbohydrates, amino acids, B vitamins and organic salts were successfully applied for stabilization of [¹⁸F]FDG.

Keywords: Radiochemical stability; Radiolysis; Scavengers; [(18)F]FDG.