Regioselective O-glycosylation of flavonoids by fungi Beauveria bassiana, Absidia coerulea and Absidia glauca

Bioorg Chem. 2019 Dec:93:102750. doi: 10.1016/j.bioorg.2019.01.046. Epub 2019 Feb 7.

Abstract

In the present study, the species: Beauveria bassiana, Absidia coerulea and Absidia glauca were used in biotransformation of flavones (chrysin, apigenin, luteolin, diosmetin) and flavanones (pinocembrin, naringenin, eriodictyol, hesperetin). The Beauveria bassiana AM 278 strain catalyzed the methylglucose attachment reactions to the flavonoid molecule at positions C7 and C3'. The application of the Absidia genus (A. coerulea AM 93, A. glauca AM 177) as the biocatalyst resulted in the formation of glucosides with a sugar molecule present at C7 and C3' positions of flavonoids skeleton. Nine of obtained products have not been previously reported in the literature.

Keywords: Absidia coerulea; Absidia glauca; Beauveria bassiana; Biotransformation; Flavanones; Flavones; Microbial glycosylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absidia / metabolism*
  • Beauveria / metabolism*
  • Biotransformation
  • Flavonoids / chemistry
  • Flavonoids / metabolism*
  • Glucosides / metabolism
  • Glycosylation
  • Molecular Structure

Substances

  • Flavonoids
  • Glucosides