Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer

Trends Cancer. 2019 Feb;5(2):82-84. doi: 10.1016/j.trecan.2018.12.001. Epub 2018 Dec 21.

Abstract

The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures. We suggest that these unique isoforms play a role in the pathogenesis of HNSCC.

Keywords: FXR1; isoforms; muscle; squamous cell carcinoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology
  • Head and Neck Neoplasms / genetics*
  • Head and Neck Neoplasms / pathology
  • Humans
  • Muscles / metabolism*
  • Protein Isoforms / metabolism*
  • RNA-Binding Proteins / metabolism*

Substances

  • FXR1 protein, human
  • Protein Isoforms
  • RNA-Binding Proteins