The Origin of CIMP, At Last

Toshikazu Ushijima; Hiromu Suzuki

doi:10.1016/j.ccell.2019.01.015

The Origin of CIMP, At Last

Cancer Cell. 2019 Feb 11;35(2):165-167. doi: 10.1016/j.ccell.2019.01.015.

Authors

Toshikazu Ushijima¹, Hiromu Suzuki²

Affiliations

¹ Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045 Tokyo, Japan. Electronic address: tushijim@ncc.go.jp.
² Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, Sapporo 060-8556, Japan.

PMID: 30753821
DOI: 10.1016/j.ccell.2019.01.015

Abstract

In this issue of Cancer Cell, Tao et al. provide compelling evidence that aging-like DNA methylation of multiple CpG islands, the CpG island methylator phenotype (CIMP), produces a cellular context that can tolerate BRAF activation avoiding senescence by dedicating 5-month culture of colon-derived organoids to epigenomic and stemness analysis.

Publication types

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MeSH terms

Carcinogenesis
CpG Islands
DNA Methylation*
Epigenesis, Genetic
Humans
Mutation
Phenotype
Proto-Oncogene Proteins B-raf / genetics*

Substances

Proto-Oncogene Proteins B-raf