Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors

Chiara Gorrini; Tak W Mak

doi:10.1016/j.ccell.2019.01.017

Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors

Cancer Cell. 2019 Feb 11;35(2):161-163. doi: 10.1016/j.ccell.2019.01.017.

Authors

Chiara Gorrini¹, Tak W Mak²

Affiliations

¹ The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, M5G 2M9, Toronto, Canada.
² The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, M5G 2M9, Toronto, Canada. Electronic address: tak.mak@uhnresearch.ca.

PMID: 30753819
DOI: 10.1016/j.ccell.2019.01.017

Abstract

In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations.

Publication types

Comment

MeSH terms

Amino Acid Transport System y+*
DNA-Binding Proteins
Glutathione
Humans
Mutation
Neoplasms*
Nuclear Proteins
Transcription Factors

Substances

ARID1A protein, human
Amino Acid Transport System y+
DNA-Binding Proteins
Nuclear Proteins
Transcription Factors
Glutathione