The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam

Doanh Le Huu; Thao Ngo Minh; Thuong Nguyen Van; Phuong Pham Thi Minh; Nghi Dinh Huu; Van Tran Cam; My Le Huyen; Minh Vu Nguyet; Mai Le Thi; Hien Do Thi Thu; Khang Tran Hau; Marco Gandolfi; Francesca Satolli; Claudio Feliciani; Michael Tirant; Aleksandra Vojvodic; Torello Lotti

doi:10.3889/oamjms.2019.055

The Effectiveness of Narrow Band Uvb (Nb-Uvb) In the Treatment of Pityriasis Lichenoides Chronica (PLC) In Vietnam

Open Access Maced J Med Sci. 2019 Jan 25;7(2):221-223. doi: 10.3889/oamjms.2019.055. eCollection 2019 Jan 30.

Authors

Doanh Le Huu^{1

2}, Thao Ngo Minh¹, Thuong Nguyen Van^{1

2}, Phuong Pham Thi Minh¹, Nghi Dinh Huu^{1

2}, Van Tran Cam¹, My Le Huyen¹, Minh Vu Nguyet^{1

2}, Mai Le Thi¹, Hien Do Thi Thu¹, Khang Tran Hau^{1

2}, Marco Gandolfi³, Francesca Satolli³, Claudio Feliciani³, Michael Tirant^{4

5}, Aleksandra Vojvodic⁶, Torello Lotti⁴

Affiliations

¹ National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
² Hanoi Medical University, Vietnam.
³ Unit of Dermatology, University of Parma, Parma, Italy.
⁴ University of Rome G. Marconi, Rome, Italy.
⁵ Psoriasis Eczema Clinic, Melbourne, Australia.
⁶ Department of Dermatology and Venereology Military Medical Academy, Belgrade, Serbia.

Abstract

Aim: This prospective clinical study presents the experiences with NB-UVB monotherapy in the treatment of PLC on Vietnamese patients.

Methods: We enrolled at National Hospital of Dermatology and Venereology (NHDV), Vietnam, 29 PLC patients with generalised disease involving at least 60% of the total body surface (based on Nine's Rule) and/or failed to respond to other modalities of treatment. Patients were treated with NB-UVB followed the guideline of the psoriatic treatment of AAD-2010, three times weekly.

Results: A complete response (CR) was seen in 24 out of 29 PLC patients (82.8%) with a mean cumulative dose of 9760.5 mJ/cm² after a mean treatment period of 4.6 weeks (13.8 ± 7.4 exposures). Mild side effects were observed: 69% erythema minimum, 55.2% irritation related to dry skin. No severe side effects were seen during the study. No relapses occurred in 24 CR patients within a mean period of 3 months after the last treatment.

Conclusion: NB-UVB therapy is an effective and safe option for the treatment and management of PLC.

Keywords: Effectiveness; NB-UVB; Phototherapy; Pityriasis lichenoides chronica; Safety.