A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection

Chem Commun (Camb). 2019 Feb 21;55(17):2541-2544. doi: 10.1039/c8cc10286d.

Abstract

A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.

MeSH terms

  • A549 Cells
  • Aniline Compounds / chemical synthesis
  • Aniline Compounds / chemistry*
  • Animals
  • Benzopyrans / chemical synthesis
  • Benzopyrans / chemistry*
  • Carbon Tetrachloride
  • Chemical and Drug Induced Liver Injury / diagnostic imaging*
  • Female
  • Fibrin / chemistry
  • Fibronectins / chemistry
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Humans
  • Mice, Inbred BALB C
  • Microscopy, Fluorescence / methods
  • Neoplasms / diagnostic imaging*
  • Oligopeptides / chemistry

Substances

  • Aniline Compounds
  • Benzopyrans
  • Fibronectins
  • Fluorescent Dyes
  • Oligopeptides
  • cysteinyl-arginyl-glutamyl-lysyl-alanyl
  • Fibrin
  • Carbon Tetrachloride