Application of molecularly imprinted polymer nanoparticles for degradation of the bacterial autoinducer N-hexanoyl homoserine lactone

J Garcia Lopez; E V Piletska; M J Whitcombe; J Czulak; S A Piletsky

doi:10.1039/c8cc07685e

Application of molecularly imprinted polymer nanoparticles for degradation of the bacterial autoinducer N-hexanoyl homoserine lactone

Chem Commun (Camb). 2019 Feb 26;55(18):2664-2667. doi: 10.1039/c8cc07685e.

Authors

J Garcia Lopez¹, E V Piletska, M J Whitcombe, J Czulak, S A Piletsky

Affiliation

¹ Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. ep219@le.ac.uk.

PMID: 30742141
DOI: 10.1039/c8cc07685e

Abstract

A novel bacterial quorum quenching system is presented. For the first time the degradation of N-l-hexanoyl homoserine lactone (C6-AHL), a Gram-negative quorum sensing autoinducer, has been enhanced using molecularly imprinted nanoparticles (MIP NPs) which were prepared using transition state analogue of the γ-lactone ring hydrolysis as template.