Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B

Vrushali P Abhyankar; Amber M Bates; Carol L Fischer; Georgia K Johnson; Janet M Guthmiller; Ann Progulske-Fox; Kim A Brogden

doi:10.1016/j.dib.2018.12.087

Dataset on the chemokine and cytokine responses of multi-cell cultures treated with Porphyromonas gingivalis hemagglutinin B

Data Brief. 2018 Dec 31:22:964-970. doi: 10.1016/j.dib.2018.12.087. eCollection 2019 Feb.

Authors

Vrushali P Abhyankar¹, Amber M Bates², Carol L Fischer³, Georgia K Johnson⁴, Janet M Guthmiller⁵, Ann Progulske-Fox⁶, Kim A Brogden^{4

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Affiliations

¹ Department of Periodontology, University of Tennessee, College of Dentistry, TN 38163, USA.
² Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA.
³ Department of Biology, Waldorf University, Forest City, IA 50436, USA.
⁴ Department of Periodontics, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA.
⁵ College of Dentistry, University of Nebraska Medical Center, Lincoln, NE 68583, USA.
⁶ Center for Molecular Microbiology and Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA.
⁷ Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA.

Abstract

Chemokines and cytokines produced in gingival tissues exposed to microorganisms and microbial products in dental plaque lead to local inflammation and tissue damage seen in periodontal disease. Bates et al. 2018 [1] reported that Porphyromonas gingivalis hemagglutinin B (HagB)-induced matrix metalloproteinase (MMP) responses of single cell cultures containing dendritic cells, gingival epithelial (GE) keratinocytes, or T cells were significantly different from the MMP responses of these same cells grown in multi-cell cultures. Here we report the concentrations (pg/ml) of HagB-induced IL1α, IL6, IL8, IL12(p40), GM-CSF, MIP1α, MIP1β, RANTES, TNFα, and VEGF produced by dendritic cells, GE keratinocytes, or T cells in single cell cultures, two-cell cultures, or three-cell cultures.

Keywords: Cytokines; Dendritic cells; Hemagglutinin B; Keratinocytes; Periodontal disease; Porphyromonas gingivalis; T cells.

Grants and funding

T90 DE023520/DE/NIDCR NIH HHS/United States