Bacteriocin encapsulation for food and pharmaceutical applications: advances in the past 20 years

Biotechnol Lett. 2019 May;41(4-5):453-469. doi: 10.1007/s10529-018-02635-5. Epub 2019 Feb 9.

Abstract

The encapsulation of bacteriocins from lactic acid bacteria has involved several methods to protect them from unfavourable environmental conditions and incompatibilities. This review encompasses different methods for the encapsulation of bacteriocins and their applications in both food and pharmaceutical fields. Based on the bibliometric analysis of publications from well-reputed journals including different available patents during the period from 1996 to 2017, 135 articles and 60 patents were collected. Continent-wise contributions to the bacteriocins encapsulation research were carried out by America (52%), Asia (29%) and Europe (19%); with the United States of America, Brazil, Thailand and Italy the countries with major contributions. Till date, different methods proposed for encapsulation have been (i) Film coatings (50%), (ii) Liposomes (23%), (iii) Nanofibers (22%) and (iv) Nanoparticles (4%). Bacteriocins encapsulation methods frequently carried out in food protection (70%); while in the pharmaceutical field, 30% of the research was conducted on multi drug resistant therapy.

Keywords: Antimicrobial activity; Bacteriocins; Drug delivery; Encapsulation; Nanotechnology.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Infections / drug therapy*
  • Bacteriocins / pharmacology*
  • Drug Compounding / methods*
  • Food Preservatives / pharmacology*
  • Technology, Pharmaceutical / methods*
  • Technology, Pharmaceutical / trends

Substances

  • Anti-Bacterial Agents
  • Bacteriocins
  • Food Preservatives