Nanohole array plasmonic biosensors: Emerging point-of-care applications

Alisha Prasad; Junseo Choi; Zheng Jia; Sunggook Park; Manas Ranjan Gartia

doi:10.1016/j.bios.2019.01.037

Nanohole array plasmonic biosensors: Emerging point-of-care applications

Biosens Bioelectron. 2019 Apr 1:130:185-203. doi: 10.1016/j.bios.2019.01.037. Epub 2019 Jan 24.

Authors

Alisha Prasad¹, Junseo Choi², Zheng Jia², Sunggook Park³, Manas Ranjan Gartia⁴

Affiliations

¹ Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
² Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA; NIH Center for BioModular Multiscale Systems for Precision Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
³ Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA; NIH Center for BioModular Multiscale Systems for Precision Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: sunggook@lsu.edu.
⁴ Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address: mgartia@lsu.edu.

Abstract

Point-of-care (POC) applications have expanded hugely in recent years and is likely to continue, with an aim to deliver cheap, portable, and reliable devices to meet the demands of healthcare industry. POC devices are designed, prototyped, and assembled using numerous strategies but the key essential features that biosensing devices require are: (1) sensitivity, (2) selectivity, (3) specificity, (4) repeatability, and (5) good limit of detection. Overall the fabrication and commercialization of the nanohole array (NHA) setup to the outside world still remains a challenge. Here, we review the various methods of NHA fabrication, the design criteria, the geometrical features, the effects of surface plasmon resonance (SPR) on sensing as well as current state-of-the-art of existing NHA sensors. This review also provides easy-to-understand examples of NHA-based POC biosensing applications, its current status, challenges, and future prospects.

Keywords: Category of sensors; Geometrical parameters; Micro/nano-fabrication; Nanohole array; Plasmonic biosensors; Point-of-care biosensing.

Publication types

Review

MeSH terms

Biosensing Techniques / methods*
Humans
Limit of Detection
Nanostructures / chemistry*
Point-of-Care Systems*
Sensitivity and Specificity
Surface Plasmon Resonance

Grants and funding

P41 EB020594/EB/NIBIB NIH HHS/United States