Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Tarek Magdy; Paul W Burridge

doi:10.1016/j.stem.2019.01.008

Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease

Cell Stem Cell. 2019 Feb 7;24(2):203-205. doi: 10.1016/j.stem.2019.01.008.

Authors

Tarek Magdy¹, Paul W Burridge²

Affiliations

¹ Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
² Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: paul.burridge@northwestern.edu.

Abstract

Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.

Publication types

Comment

MeSH terms

Cardiovascular Diseases*
Chromosomes, Human, Pair 9
Coronary Artery Disease*
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Phenotype
Polymorphism, Single Nucleotide
Risk Factors

Grants and funding

R01 CA220002/CA/NCI NIH HHS/United States