Abstract
In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.
MeSH terms
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Animals
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Biocompatible Materials / chemical synthesis
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Biocompatible Materials / chemistry
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Biocompatible Materials / pharmacology*
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Bone Regeneration / drug effects
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Bone and Bones / drug effects*
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Integrin alpha5beta1 / chemistry
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Integrin alphaVbeta3 / chemistry
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Ligands
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Mesenchymal Stem Cells / drug effects*
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Molecular Structure
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Peptidomimetics / chemistry
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Peptidomimetics / pharmacology*
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Rats
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Titanium / chemistry
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Titanium / pharmacology
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Wound Healing / drug effects
Substances
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Biocompatible Materials
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Integrin alpha5beta1
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Integrin alphaVbeta3
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Ligands
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Oligopeptides
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Peptidomimetics
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arginyl-glycyl-aspartic acid
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Titanium