Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands

Biomater Sci. 2019 Mar 26;7(4):1281-1285. doi: 10.1039/c8bm01466c.

Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology*
  • Bone Regeneration / drug effects
  • Bone and Bones / drug effects*
  • Integrin alpha5beta1 / chemistry
  • Integrin alphaVbeta3 / chemistry
  • Ligands
  • Mesenchymal Stem Cells / drug effects*
  • Molecular Structure
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology*
  • Peptidomimetics / chemistry
  • Peptidomimetics / pharmacology*
  • Rats
  • Titanium / chemistry
  • Titanium / pharmacology
  • Wound Healing / drug effects

Substances

  • Biocompatible Materials
  • Integrin alpha5beta1
  • Integrin alphaVbeta3
  • Ligands
  • Oligopeptides
  • Peptidomimetics
  • arginyl-glycyl-aspartic acid
  • Titanium