Abstract
A series of near-infrared fluorescent probes based on inhibitor (clorgyline) structure-guided design were synthesized for the specific detection of MAO-A in cells and in vivo. Moreover, we have successfully used the high specificity of one of the probes to visualize MAO-A activity in zebrafish and tumor tissue for the first time.
MeSH terms
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Animals
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Cell Line, Tumor
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Clorgyline / analogs & derivatives*
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Clorgyline / chemical synthesis
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Clorgyline / toxicity
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Drug Design
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Fluorescent Dyes / toxicity
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Humans
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Limit of Detection
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Mice, Inbred BALB C
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Microscopy, Fluorescence / methods
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Molecular Structure
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Monoamine Oxidase / analysis*
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Monoamine Oxidase / metabolism*
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Monoamine Oxidase Inhibitors / chemical synthesis
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Monoamine Oxidase Inhibitors / chemistry*
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Monoamine Oxidase Inhibitors / toxicity
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Zebrafish
Substances
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Fluorescent Dyes
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Monoamine Oxidase Inhibitors
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Monoamine Oxidase
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Clorgyline