Embracing Noise in Chemical Reaction Networks

Bull Math Biol. 2019 May;81(5):1261-1267. doi: 10.1007/s11538-019-00575-3.

Abstract

We provide a short review of stochastic modeling in chemical reaction networks for mathematical and quantitative biologists. We use as case studies two publications appearing in this issue of the Bulletin, on the modeling of quasi-steady-state approximations and cell polarity. Reasons for the relevance of stochastic modeling are described along with some common differences between stochastic and deterministic models.

Keywords: Chemical reaction network; Noise; Scaling limit; Stochasticity; Systems biology.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Polarity / physiology
  • Humans
  • Kinetics
  • Mathematical Concepts
  • Metabolic Networks and Pathways
  • Models, Biological*
  • Models, Chemical
  • Stochastic Processes
  • Systems Biology
  • cdc42 GTP-Binding Protein / metabolism

Substances

  • cdc42 GTP-Binding Protein