Bone morphogenetic protein signaling in inflammation

Exp Biol Med (Maywood). 2019 Feb;244(2):147-156. doi: 10.1177/1535370219828694. Epub 2019 Feb 7.

Abstract

By compiling findings from recent studies, this review will garner novel insight on the dynamic and complex role of BMP signaling in diseases of inflammation, highlighting the specific roles played by both individual ligands and endogenous antagonists. Ultimately, this summary will help inform the high therapeutic value of targeting this pathway for modulating diseases of inflammation.

Keywords: Atherosclerosis; anemia of inflammation; endothelial injury; inflammatory arthritis; myocardial infarction; vascular inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anemia / metabolism
  • Anemia / physiopathology
  • Arthritis / metabolism
  • Arthritis / physiopathology
  • Bone Morphogenetic Proteins / metabolism
  • Bone Morphogenetic Proteins / physiology*
  • Embryonic Development
  • Fibrosis / metabolism
  • Humans
  • Inflammation / metabolism*
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / physiopathology
  • Signal Transduction
  • Vascular Calcification / metabolism

Substances

  • Bone Morphogenetic Proteins