A Fatal Case of Acute Arsenic Poisoning

J Forensic Sci. 2019 Jul;64(4):1271-1273. doi: 10.1111/1556-4029.14017. Epub 2019 Feb 7.

Abstract

This manuscript reported a case of fatal arsenic poisoning. A woman with schizophrenia took arsenic-containing "pills," which consisted of arsenic trioxide and realgar (arsenic (II) sulfide) and wrapped with gauze. The victim consumed 1.09 and 0.819 g arsenic on two occasions, respectively, with the interval between the two doses of 3 days. The woman died on the sixth day after the first dose without any treatment. In this case, pathological examination revealed fat degeneration of the liver rather than hepatomegaly, a rare finding in acute arsenic poisoning. Arsenic in tissue samples was measured, the total arsenic and inorganic arsenic in blood, liver, and gastric wall was 10.2 μg/mL (9.61 μg/mL), 23.1 μg/g (20.7 μg/g), and 32.3 μg/g (28.6 μg/g), respectively.

Keywords: arsenic trioxide; fatality; forensic science; forensic toxicology; realgar; tissue concentration.

Publication types

  • Case Reports

MeSH terms

  • Arsenic Poisoning / diagnosis*
  • Arsenic Trioxide / analysis
  • Arsenic Trioxide / poisoning
  • Arsenicals / analysis
  • China
  • Fatal Outcome
  • Fatty Liver / chemically induced
  • Fatty Liver / pathology
  • Female
  • Humans
  • Liver / chemistry
  • Quackery
  • Schizophrenia
  • Stomach / chemistry
  • Sulfides / analysis
  • Sulfides / poisoning
  • Young Adult

Substances

  • Arsenicals
  • Sulfides
  • arsenic disulfide
  • Arsenic Trioxide