Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering

Tyler Hoffman; Ali Khademhosseini; Robert Langer

doi:10.1089/ten.TEA.2019.0032

Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering

Tissue Eng Part A. 2019 May;25(9-10):679-687. doi: 10.1089/ten.TEA.2019.0032.

Authors

Tyler Hoffman^{1

2

3}, Ali Khademhosseini^{1

2

3

4

5

6}, Robert Langer^{7

8

9

10}

Affiliations

¹ 1 Department of Bioengineering, University of California, Los Angeles, California.
² 2 Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, California.
³ 3 California NanoSystems Institute (CNSI), University of California, Los Angeles, California.
⁴ 4 Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California.
⁵ 5 Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California.
⁶ 6 Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California.
⁷ 7 David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
⁸ 8 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
⁹ 9 Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts.
¹⁰ 10 Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Abstract

In this Perspective, we discuss the impact of the past 25 years of tissue engineering on the development of clinical therapies. Based on their success and other significant research accomplishments, platforms of innovation were identified. Their discoveries will enable tissue engineering inspired therapies to meet the requirements necessary for large-scale manufacturing and Food and Drug Administration (FDA) approval for a diverse range of indications.

Keywords: 3D bioprinting; clinical; personalized medicine; regenerative medicine; tissue engineering.

Publication types

Historical Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Bioprinting / history*
History, 20th Century
History, 21st Century
Humans
Printing, Three-Dimensional / history*
Regenerative Medicine / history*
Tissue Engineering / history*
Tissue Scaffolds*

Abstract

Publication types

MeSH terms

Grants and funding