Atomically-thin 2D materials have opened up new opportunities in the past decade in realizing novel electronic device concepts, owing to their unusual electronic properties. The recent progress made in the aspect of utilizing additional degrees of freedom of the electrons such as spin and valley suggests that 2D materials have a significant potential in replacing current electronic-charge-based semiconductor technology with spintronics and valleytronics. For spintronics, spin-orbit coupling plays a key role in manipulating the electrons' spin degree of freedom to encode and process information, and there are a host of recent studies exploring this facet of 2D materials. We review the recent advances in tuning spin-orbit coupling of 2D materials which are of notable importance to the progression of spintronics.