Regulatory T Cells under the Mercy of Mitochondria

Mrinmoy Das; Fawaz Alzaid; Jagadeesh Bayry

doi:10.1016/j.cmet.2019.01.012

Regulatory T Cells under the Mercy of Mitochondria

Cell Metab. 2019 Feb 5;29(2):243-245. doi: 10.1016/j.cmet.2019.01.012.

Authors

Mrinmoy Das¹, Fawaz Alzaid², Jagadeesh Bayry³

Affiliations

¹ Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Descartes, Sorbonne Paris Cité, Paris F-75006, France.
³ Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Descartes, Sorbonne Paris Cité, Paris F-75006, France. Electronic address: jagadeesh.bayry@crc.jussieu.fr.

PMID: 30726757
DOI: 10.1016/j.cmet.2019.01.012

Abstract

Mitochondria, the powerhouse of the cell, known for producing energy through oxidative phosphorylation and the Krebs cycle, continue gaining notoriety for roles beyond bioenergetics. Recently in Nature, Weinberg et al. (2019) reported that mitochondrial complex III is indispensable for suppressive function of regulatory T cells, thus highlighting the importance of mitochondria in immune tolerance.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Energy Metabolism
Humans
Mitochondria*
Mitochondrial Membranes
Oxidative Phosphorylation
T-Lymphocytes, Regulatory*