mTOR Is Key to T Cell Transdifferentiation

Jiawei Yan; Ruoning Wang; Tiffany Horng

doi:10.1016/j.cmet.2019.01.008

mTOR Is Key to T Cell Transdifferentiation

Cell Metab. 2019 Feb 5;29(2):241-242. doi: 10.1016/j.cmet.2019.01.008.

Authors

Jiawei Yan¹, Ruoning Wang², Tiffany Horng³

Affiliations

¹ School of Life Sciences and Technology, ShanghaiTech University.
² Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's Hospital, Ohio State University. Electronic address: ruoning.wang@nationwidechildrens.org.
³ School of Life Sciences and Technology, ShanghaiTech University. Electronic address: tsyhorng@shanghaitech.edu.cn.

Abstract

T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Autoimmunity
Cell Transdifferentiation*
Humans
Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases
Th17 Cells*

Substances

Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding