How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins

Sharanbasappa S Karade; Roy A Mariuzza

doi:10.1016/j.str.2019.01.007

How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins

Structure. 2019 Feb 5;27(2):209-210. doi: 10.1016/j.str.2019.01.007.

Authors

Sharanbasappa S Karade¹, Roy A Mariuzza²

Affiliations

¹ University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
² University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. Electronic address: rmariuzz@umd.edu.

PMID: 30726753
DOI: 10.1016/j.str.2019.01.007

Abstract

The cytolytic activity of NK cells is regulated by activating and inhibitory receptors, including ones that recognize cell-cell adhesion molecules. In this issue of Structure, Deuss et al. (2019) report the structure of nectin-like protein-5 bound to the NK inhibitory receptor CD96, a promising new target for cancer immunotherapy.

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MeSH terms

Antigens, CD*
Cell Adhesion
Nectins
Receptors, Immunologic*
Receptors, Natural Killer Cell

Substances

Antigens, CD
Nectins
Receptors, Immunologic
Receptors, Natural Killer Cell