Fibrinogen

Excerpt

Fibrinogen is a 340kDa hexameric plasma glycoprotein synthesized by the liver and is the major structural component of a clot. The type of fibrinogen disorders that require replacement therapy can be congenital or acquired. There can be an abnormality in the amount or function of circulating fibrinogen. This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, monitoring, and toxicity of fibrinogen replacement so that providers can direct patient therapy to optimal outcomes.