HIV-1 Drug Resistance and Virologic Outcomes Among Tanzanian Youth Living With HIV

Pediatr Infect Dis J. 2019 Jun;38(6):617-619. doi: 10.1097/INF.0000000000002288.

Abstract

Adolescents living with HIV tend to have poor adherence that often breeds HIV resistance mutations and virologic failure (VF). This study evaluated risk behavior, virologic outcomes and HIV resistance mutations in Tanzanian youth living with HIV. Participants were primarily perinatally infected and of mean age 16.7 years; among them 41.5% had VF. Those receiving first-line therapy demonstrated over 90% resistance to their current therapy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • Cross-Sectional Studies
  • Drug Resistance, Viral*
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / transmission
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Health Risk Behaviors
  • Humans
  • Male
  • Medication Adherence
  • Mutation
  • Prospective Studies
  • RNA, Viral / blood
  • Risk Factors
  • Tanzania
  • Treatment Failure
  • Treatment Outcome
  • Viral Load / drug effects
  • Young Adult

Substances

  • Anti-HIV Agents
  • RNA, Viral