Data on the inhibition of cell proliferation and invasion by the D2A-Ala peptide derived from the urokinase receptor

Federico Furlan; Gabriele Eden; Marco Archinti; Ralitsa Arnaudova; Giuseppina Andreotti; Valentina Citro; Maria Vittoria Cubellis; Andrea Motta; Bernard Degryse

doi:10.1016/j.dib.2019.01.009

Data on the inhibition of cell proliferation and invasion by the D2A-Ala peptide derived from the urokinase receptor

Data Brief. 2019 Jan 9:22:903-908. doi: 10.1016/j.dib.2019.01.009. eCollection 2019 Feb.

Authors

Federico Furlan¹, Gabriele Eden², Marco Archinti¹, Ralitsa Arnaudova¹, Giuseppina Andreotti³, Valentina Citro⁴, Maria Vittoria Cubellis⁴, Andrea Motta³, Bernard Degryse¹

Affiliations

¹ Dept. of Molecular Biology and Functional Genomics, DIBIT, Università Vita-Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy.
² IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
³ Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli (Naples), Italy.
⁴ Dipartimento di Biologia, Università Federico II, Naples, Italy.

Abstract

The data presented in this article are connected to our research article entitled "D2A-Ala peptide derived from the urokinase receptor exerts anti-tumoural effects in vitro and in vivo" (Furlan et al., 2018). These data further extend our understanding of the inhibitory effects of D2A-Ala peptide. Dose-response curve using a wide range of concentrations of D2A-Ala shows that this peptide has no effects per se on proliferation of rat smooth muscle cells (RSMC). However, D2A-Ala dose-dependently inhibits epidermal growth factor (EGF)-induced RSMC proliferation. Kinetics lasting up to seven days revealed that D2A-Ala peptide completely blocked EGF-promoted RSMC proliferation. Moreover, D2A-Ala peptide inhibited invasion of HT 1080 cells towards RSMC.

Keywords: Cell invasion; Cell proliferation; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; Peptide; RSMC, rat smooth muscle cells; Urokinase receptor; uPAR, urokinase receptor.