The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

Jin Szatkiewicz; James J Crowley; Annelie Nordin Adolfsson; Karolina A Åberg; Maaike Alaerts; Giulio Genovese; Steven McCarroll; Jurgen Del-Favero; Rolf Adolfsson; Patrick F Sullivan

doi:10.1038/s41398-019-0414-9

The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

Transl Psychiatry. 2019 Feb 4;9(1):60. doi: 10.1038/s41398-019-0414-9.

Authors

Affiliations

¹ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Clinical Sciences and Psychiatry, University of Umeå, Umeå, Sweden.
³ Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USA.
⁴ Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.
⁵ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶ VIB Center for Molecular Neurology, Universiteitsplein 1, Antwerp, Belgium and Multiplicom N.V., Galileilaan 18, Niel, Belgium.
⁷ Department of Clinical Sciences and Psychiatry, University of Umeå, Umeå, Sweden. rolf.adolfsson@umu.se.
⁸ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.
⁹ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.
¹⁰ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. pfsulliv@med.unc.edu.

Abstract

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Bipolar Disorder / epidemiology
Bipolar Disorder / genetics*
Case-Control Studies
Exome Sequencing / methods
Female
Genomics / methods*
Humans
Karyotyping / methods
Male
Middle Aged
Oligonucleotide Array Sequence Analysis / methods
Pedigree
Polymorphism, Single Nucleotide
Psychotic Disorders / epidemiology
Psychotic Disorders / genetics*
Schizophrenia / epidemiology
Schizophrenia / genetics*
Sweden / epidemiology
Whole Genome Sequencing / methods

Abstract

Publication types

MeSH terms

Grants and funding