Skin IL-17-Producing T Cells Support Repair 2!

Daniel F Zegarra-Ruiz; Gretchen E Diehl

doi:10.1016/j.it.2019.01.004

Skin IL-17-Producing T Cells Support Repair 2!

Trends Immunol. 2019 Mar;40(3):177-179. doi: 10.1016/j.it.2019.01.004. Epub 2019 Feb 2.

Authors

Daniel F Zegarra-Ruiz¹, Gretchen E Diehl²

Affiliations

¹ Alkek Center for Metagenomics and Microbiome Research, and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
² Alkek Center for Metagenomics and Microbiome Research, and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: gdiehl@bcm.edu.

PMID: 30718047
DOI: 10.1016/j.it.2019.01.004

Abstract

In a recent study, Harrison et al. (Science 2019;363;eaat6280) report that RORγt-expressing skin commensal-specific T cells rapidly respond to tissue wounding by producing type 2 T helper cell (Th2) cytokines in mice. The cells constitutively coexpress GATA-3 and type 2 cytokine mRNAs that are translated after injury. These T cells act as sentinels, linking T cell receptor (TCR) recognition of commensals, tissue damage, and wound repair.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytokines / metabolism
Humans
Immunity, Cellular
Mice
Microbiota / immunology*
Nuclear Receptor Subfamily 1, Group F, Member 3 / metabolism
Receptors, Antigen, T-Cell / metabolism
Th2 Cells / immunology*
Wound Healing*

Substances

Cytokines
Nuclear Receptor Subfamily 1, Group F, Member 3
Receptors, Antigen, T-Cell