Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease

Ágnes Fehér; Anna Juhász; Magdolna Pákáski; Zoltán Janka; János Kálmán

doi:10.1016/j.psychres.2019.01.081

Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease

Psychiatry Res. 2019 Sep:279:376-377. doi: 10.1016/j.psychres.2019.01.081. Epub 2019 Jan 26.

Authors

Ágnes Fehér¹, Anna Juhász², Magdolna Pákáski², Zoltán Janka², János Kálmán²

Affiliations

¹ Department of Psychiatry, University of Szeged, 57 Kálvária Ave, Szeged, H-6724 Hungary. Electronic address: feher.agnes@med.u-szeged.hu.
² Department of Psychiatry, University of Szeged, 57 Kálvária Ave, Szeged, H-6724 Hungary.

PMID: 30717989
DOI: 10.1016/j.psychres.2019.01.081

Abstract

The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD). Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. A modest, marginally significant association of the G allele containing genotypes with AD was observed (p = 0.054). In line with the previous results in other populations, the G allele carriers had an increased risk for developing AD considering C/C genotype as reference category.

Keywords: ABCA7; APOE; Alzheimer's disease; Association study; rs3752246.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ATP-Binding Cassette Transporters / genetics*
Aged
Aged, 80 and over
Alzheimer Disease / diagnosis*
Alzheimer Disease / genetics*
Case-Control Studies
Female
Genetic Association Studies / methods*
Genetic Predisposition to Disease / genetics
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*

Substances

ABCA7 protein, human
ATP-Binding Cassette Transporters