Toxic effects of magnetic nanoparticles on normal cells and organs

Life Sci. 2019 Mar 1:220:156-161. doi: 10.1016/j.lfs.2019.01.056. Epub 2019 Feb 1.

Abstract

Magnetic nanoparticles (MNPs) are promising candidates for drug delivery and treatment of various disorders. Toxicity evaluation is a critical point in the development of nanoformulations and therefore, draws considerable attention. Formulations involving individual or combinatorial nanoparticle suspensions might be used for targeted delivery and treatment. This might be a evaluated further for safety related issues considering future medications based on MNPs. Nanoparticle distribution in the body is dependent on its surface characteristics. Size, dose and routes of nanoparticle entry have to be taken into consideration for future assays.

Keywords: Drug delivery; Magnetic nanoparticles; Nanoformulation; Target specificity; Toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / adverse effects
  • Humans
  • Magnetite Nanoparticles / adverse effects
  • Magnetite Nanoparticles / toxicity*
  • Nanoparticles / adverse effects*
  • Nanoparticles / toxicity
  • Pharmaceutical Preparations

Substances

  • Magnetite Nanoparticles
  • Pharmaceutical Preparations