Considering the 'Alternatives' for Next-Generation Anti-Staphylococcus aureus Vaccine Development

Trends Mol Med. 2019 Mar;25(3):171-184. doi: 10.1016/j.molmed.2018.12.010. Epub 2019 Jan 31.

Abstract

Staphylococcus aureus is an opportunistic pathogen, which can readily develop antibiotic resistance and result in severe disease. To combat antibiotic resistance, new treatment strategies are being developed with a particular focus on vaccine development. S. aureus vaccines that target humoral immunity alone do not provide sufficient protection from all disease phenotypes associated with this pathogen. Recent studies have identified the requirement for cellular immunity to provide a robust immune response to this infection. Driving conventional T cell responses has therefore become the focus of intense research in this area. Recently described 'alternative' T cells could provide a novel strategy for improving therapeutic efficacy and success in next-generation anti-S. aureus vaccine design.

Keywords: MAIT cells; Staphylococcus aureus; innate lymphoid cells; γδ cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Susceptibility / immunology
  • Humans
  • Immunity, Cellular
  • Immunity, Innate
  • Immunologic Memory
  • Receptors, Antigen, T-Cell, gamma-delta / genetics
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism
  • Staphylococcal Infections / immunology*
  • Staphylococcal Infections / metabolism
  • Staphylococcal Infections / prevention & control*
  • Staphylococcal Vaccines / immunology*
  • Staphylococcus aureus / immunology*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism

Substances

  • Receptors, Antigen, T-Cell, gamma-delta
  • Staphylococcal Vaccines