Anticatabolic Effects of Ketone Bodies in Skeletal Muscle

Abstract

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis.

Keywords: acetoacetate; atrophy; cachexia; inflammation; muscle protein breakdown; β-hydroxybutyrate.