D-penicillamine-induced pseudo-pseudoxanthoma elasticum and extensive elastosis perforans serpiginosa with excellent response to acitretin

Muzamil Amin Chisti; Yousef Binamer; Abdullah Alfadley; Abdulmonem Almutawa

doi:10.5144/0256-4947.2019.56

D-penicillamine-induced pseudo-pseudoxanthoma elasticum and extensive elastosis perforans serpiginosa with excellent response to acitretin

Ann Saudi Med. 2019 Jan-Feb;39(1):56-60. doi: 10.5144/0256-4947.2019.56.

Authors

Muzamil Amin Chisti¹, Yousef Binamer, Abdullah Alfadley, Abdulmonem Almutawa

Affiliation

¹ Dr. Muzamil Amin Chisti, MBC 46 Department of Dermatology,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211, Saudi Arabia, T: +966114424608, jan.phiny@gmail.com, ORCID: http:// orcid.org/0000-0002-6877-2715.

Abstract

D-penicillamine (DPA)-induced pseudo-pseudoxanthoma elasticum (PXE) and elastosis perforans serpiginosa (EPS) has been reported in the past, but most of the treatment modalities used before have a sub.optimal response. We report a case of DPA-induced pseudo-PXE with extensive EPS who had an excellent rapid response to acitretin. To the best of our knowledge no such report has been published in the past, even though there is a single report of effectiveness of isotretinoin in elastosis perforans serpiginosa. SIMILAR CASES PUBLISHED: One similar case but with a different medication (reference 13).

Publication types

Case Reports

MeSH terms

Acitretin / therapeutic use*
Adult
Hepatolenticular Degeneration / drug therapy
Humans
Keratolytic Agents / therapeutic use*
Male
Penicillamine / adverse effects*
Pseudoxanthoma Elasticum / chemically induced
Pseudoxanthoma Elasticum / drug therapy*
Skin Diseases / chemically induced
Skin Diseases / drug therapy*
Treatment Outcome

Substances

Keratolytic Agents
Penicillamine
Acitretin

Supplementary concepts

Elastosis perforans serpiginosa