Poly (N-isopropylacrylamide) based hydrogels as novel precipitation and stabilization media for solid lipid nanoparticles (SLNs)

Sushilkumar A Jadhav; Valentina Brunella; Simona Sapino; Bruno Caprarelli; Chiara Riedo; Daniela Chirio; Marina Gallarate

doi:10.1016/j.jcis.2019.01.107

Poly (N-isopropylacrylamide) based hydrogels as novel precipitation and stabilization media for solid lipid nanoparticles (SLNs)

J Colloid Interface Sci. 2019 Apr 1:541:454-460. doi: 10.1016/j.jcis.2019.01.107. Epub 2019 Jan 25.

Authors

Sushilkumar A Jadhav¹, Valentina Brunella², Simona Sapino³, Bruno Caprarelli³, Chiara Riedo⁴, Daniela Chirio³, Marina Gallarate³

Affiliations

¹ Department of Chemistry and NIS Research Centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy; School of Nanoscience and Technology, Shivaji University Kolhapur, 416004 Kolhapur, Maharashtra, India. Electronic address: sushil.unige@gmail.com.
² Department of Chemistry and NIS Research Centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy. Electronic address: valentina.brunella@unito.it.
³ Dipartimento di Scienza e Tecnologia del Farmaco, University of Torino, Via P. Giuria 9, 10125 Torino, Italy.
⁴ Department of Chemistry and NIS Research Centre, University of Torino, Via P. Giuria 7, 10125 Torino, Italy.

PMID: 30711639
DOI: 10.1016/j.jcis.2019.01.107

Abstract

In this work, poly(N-isopropylacrylamide) (PNIPAM) based chemically cross-linked hydrogels are used as novel precipitation and stabilization media for solid lipid nanoparticles (SLNs) for the first time. The hydrogels and the hybrid thermoresponsive composite hydrogels with SLNs were characterized by SEM, DSC, DLS and rheometric analysis. The results showed that the SLNs obtained directly in the gel matrix by the newly devised method were well-dispersed and remained stable for one month. A remarkable advantage of this approach is that it yields the thermoresponsive nanocomposite hydrogels in a single step. This approach is a significant advancement in the preparation of hybrid thermoresponsive nanocomposite systems based on smart gels and SLNs for their use in biomedical applications.

Keywords: Smart polymers; Solid lipid nanoparticles (SLNs); Stability of SLNs; Thermoresponsive gels; Thermoresponsive nanocomposites.