Physiology and pathophysiology of the β3-adrenergic receptor

Li-Kun Yang; Ya-Xiong Tao

doi:10.1016/bs.pmbts.2018.09.003

Physiology and pathophysiology of the β₃-adrenergic receptor

Prog Mol Biol Transl Sci. 2019:161:91-112. doi: 10.1016/bs.pmbts.2018.09.003. Epub 2018 Oct 30.

Authors

Li-Kun Yang¹, Ya-Xiong Tao²

Affiliations

¹ Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
² Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States. Electronic address: taoyaxi@auburn.edu.

PMID: 30711031
DOI: 10.1016/bs.pmbts.2018.09.003

Abstract

The β₃-adrenergic receptor (β₃-AR) is an important regulator of various physiological functions, such as thermogenesis in brown adipose tissue, lipolysis in white adipose tissue, negative inotropic effect in cardiomyocyte, and relaxation in blood vessel. The activation of β₃-AR by its agonists is shown to have metabolic (antiobesity and antidiabetic) and cardiovascular effects in animal models, highlighting β₃-AR as a potential therapeutic target in the treatment of several human diseases. Moreover, a substantial number of studies performed on different populations have identified some β₃-AR polymorphic variants associated with obesity, diabetes, cardiovascular diseases, and other disorders. The clinical phenotypes and functional characteristics of these variants provide insights into potential pathophysiological roles of β₃-AR in the development of these diseases.

Keywords: Cardiovascular diseases; Diabetes; Obesity; Polymorphic variants; Trp64Arg; β(3)-Adrenergic receptor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Heterozygote
Humans
Polymorphism, Genetic
Receptors, Adrenergic, beta-3 / chemistry
Receptors, Adrenergic, beta-3 / genetics
Receptors, Adrenergic, beta-3 / physiology*
Signal Transduction

Substances

Receptors, Adrenergic, beta-3