Acute myeloid leukemia with central diabetes insipidus

Blood Cells Mol Dis. 2019 May:76:45-52. doi: 10.1016/j.bcmd.2019.01.005. Epub 2019 Jan 24.

Abstract

While acute myeloid leukemia (AML) is the most common type of acute leukemia in adulthood, the constellation of AML associated with central diabetes insipidus (CDI) is rare and typically occurs in patients with chromosome 3 or 7 abnormalities. This subgroup of AML is associated with a poor clinical outcome. In this report, we present a young woman with AML and concurrent CDI in the presence of inversion(3)(q21q26). The AML was refractory to the induction therapy "7 + 3". Afterwards, the patient underwent allogenic stem cell transplantation (alloHSCT) and is still remaining in complete remission (CR) from AML as well as CDI 440 days after alloHSCT. Subsequently, in the largest study concerning patients with AML and CDI reported so far, we discuss additional cases from the literature. We demonstrated that patients with AML and CDI belong to the adverse prognostic group and clearly benefit from alloHSCT.

Keywords: AML; Diabetes insipidus; Inversion 3q21q26; Monosomy 7; Myeloid.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosome Inversion
  • Chromosomes, Human, Pair 3
  • Diabetes Insipidus, Neurogenic / complications*
  • Diabetes Insipidus, Neurogenic / genetics
  • Diabetes Insipidus, Neurogenic / therapy
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / therapy
  • Prognosis
  • Remission Induction
  • Transplantation, Homologous