Bilateral cingulate cortices lesions in two autoantibodies directed against MOG (MOG-Ab)-positive patients

Takashi Kamada; Shiroh Miura; Masaya Harada; Azusa Irie; Shinsuke Kikuchi; Takayuki Taniwaki; Seiji Kurata; Yusuke Uchiyama; Toshiyuki Takahashi

doi:10.1016/j.msard.2019.01.035

Bilateral cingulate cortices lesions in two autoantibodies directed against MOG (MOG-Ab)-positive patients

Mult Scler Relat Disord. 2019 Apr:29:108-110. doi: 10.1016/j.msard.2019.01.035. Epub 2019 Jan 23.

Authors

Takashi Kamada¹, Shiroh Miura², Masaya Harada¹, Azusa Irie¹, Shinsuke Kikuchi¹, Takayuki Taniwaki¹, Seiji Kurata³, Yusuke Uchiyama³, Toshiyuki Takahashi⁴

Affiliations

¹ Department of Neurology, Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
² Department of Neurology, Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. Electronic address: shiroh46@med.kurume-u.ac.jp.
³ Department of Radiology, Kurume University School of Medicine, Japan.
⁴ Department of Neurology, Tohoku University Graduate School of Medicine, Japan; Department of Neurology, National Hospital Organization Yonezawa Hospital, Japan.

PMID: 30708307
DOI: 10.1016/j.msard.2019.01.035

Abstract

There are no specific radiologic features in MOG-Ab (autoantibodies directed against myelin oligodendrocyte glycoprotein)-associated diseases. We present two MOG-Ab-positive patients with symmetrical lesions in the bilateral cingulate cortex of the frontal and parietal lobes. Those lesions showed hyperperfusion in acute phase and hypoperfusion in chronic phase on brain SPECT. In both patients, steroid therapy was effective in acute phase and for prevention of recurrence. High signal in the bilateral cingulate cortex on MR T2-weighted and FLAIR images might to be one of the unique findings considered MOG-Ab associated diseases.

Keywords: Cingulate cortex; MRI; Myelin oligodendrocyte glycoprotein (MOG); SPECT; Treatment.

Publication types

Case Reports

MeSH terms

Acute Disease
Adult
Autoantibodies / immunology*
Chronic Disease
Demyelinating Autoimmune Diseases, CNS / diagnostic imaging
Demyelinating Autoimmune Diseases, CNS / drug therapy
Demyelinating Autoimmune Diseases, CNS / immunology
Demyelinating Autoimmune Diseases, CNS / pathology*
Female
Gyrus Cinguli / diagnostic imaging
Gyrus Cinguli / pathology*
Humans
Magnetic Resonance Imaging
Male
Myelin-Oligodendrocyte Glycoprotein / immunology*
Secondary Prevention
Steroids / pharmacology*
Tomography, Emission-Computed, Single-Photon

Substances

Autoantibodies
MOG protein, human
Myelin-Oligodendrocyte Glycoprotein
Steroids