Sudden cardiac death in a patient with LGI1 antibody-associated encephalitis

Romana Rizzi; Francesco Fisicaro; Andrea Zangrandi; Enrico Ghidoni; Simone Baiardi; Moira Ragazzi; Piero Parchi

doi:10.1016/j.seizure.2019.01.013

Sudden cardiac death in a patient with LGI1 antibody-associated encephalitis

Seizure. 2019 Feb:65:148-150. doi: 10.1016/j.seizure.2019.01.013. Epub 2019 Jan 25.

Authors

Romana Rizzi¹, Francesco Fisicaro², Andrea Zangrandi³, Enrico Ghidoni⁴, Simone Baiardi⁵, Moira Ragazzi⁶, Piero Parchi⁷

Affiliations

¹ Neurology Unit, Department of Neuro-Motor Diseases, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.
² Department of Medical and Surgical Sciences and Advanced Technologies, Section of Neurosciences, University of Catania, Catania, Italy.
³ Clinical Neuropsychology, Cognitive Disorders and Dyslexia Unit, Department of Neuro-Motor Diseases, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy. Electronic address: andrea.zangrandi89@gmail.com.
⁴ Neurology Unit, Department of Neuro-Motor Diseases, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy; Clinical Neuropsychology, Cognitive Disorders and Dyslexia Unit, Department of Neuro-Motor Diseases, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.
⁵ Department for Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
⁶ Department of Pathology, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.
⁷ IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; Department of Experimental Diagnostic and Specialty Medicine (DIMES), University of Bologna, Italy.

PMID: 30708290
DOI: 10.1016/j.seizure.2019.01.013

No abstract available

Keywords: Antibodies against anti-voltage-gated-potassium-channel (VGKC); Limbic encephalitis; Myocardial fibrosis; Myocardial ischemia; Perivascular cuffing; Sudden cardiac death.

Publication types

Case Reports
Letter

MeSH terms

Autoantibodies / immunology
Cognitive Dysfunction / diagnosis
Cognitive Dysfunction / etiology
Death, Sudden, Cardiac*
Electroencephalography
Fatal Outcome
Humans
Intracellular Signaling Peptides and Proteins
Limbic Encephalitis* / complications
Limbic Encephalitis* / diagnosis
Limbic Encephalitis* / immunology
Magnetic Resonance Imaging
Male
Middle Aged
Myocardial Ischemia / diagnosis
Proteins / immunology*
Seizures / diagnosis
Seizures / etiology

Substances

Autoantibodies
Intracellular Signaling Peptides and Proteins
LGI1 protein, human
Proteins