Metabolic Disease Epidemics: Emerging Challenges in Regenerative Medicine

Raquel Costa-Almeida; Rui L Reis; Manuela E Gomes

doi:10.1016/j.tem.2019.01.001

Metabolic Disease Epidemics: Emerging Challenges in Regenerative Medicine

Trends Endocrinol Metab. 2019 Mar;30(3):147-149. doi: 10.1016/j.tem.2019.01.001. Epub 2019 Jan 29.

Authors

Raquel Costa-Almeida¹, Rui L Reis², Manuela E Gomes³

Affiliations

¹ 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
² 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal.
³ 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal; The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal. Electronic address: megomes@i3bs.uminho.pt.

PMID: 30704823
DOI: 10.1016/j.tem.2019.01.001

Abstract

The interplay between cell/tissue damage caused by metabolic dysfunction and regenerative potential remains elusive. The tissue engineering and regenerative medicine (TERM) field is now facing a worldwide epidemic of obesity. This Forum article uncovers prospective questions to be addressed in TERM toward the development of effective regenerative therapies adjusted to these new demands.

Keywords: adipose stem cells; diabetes; metabolic syndrome; obesity; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Metabolic Diseases / therapy*
Regenerative Medicine / methods*
Tissue Engineering / methods