Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

Chin J Nat Med. 2019 Jan;17(1):22-26. doi: 10.1016/S1875-5364(19)30005-6.

Abstract

Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-α secretion inhibitory activity assay, compounds 1 and 2 were active with the IC50 of 2.6 and 3.8 μmol·L-1, respectively. In addition, compounds 1 and 2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.

Keywords: Cirsium setosum; Cytotoxicity; TNF-α secretion inhibitory activity; Taraxastane-type triterpenoid.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cirsium / chemistry*
  • Ether / chemistry
  • Humans
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Mice
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plants, Edible / chemistry*
  • Plants, Medicinal / chemistry*
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Plant Extracts
  • Triterpenes
  • Tumor Necrosis Factor-alpha
  • Ether