Cardiotonic Steroids-A Possible Link Between High-Salt Diet and Organ Damage

Aneta Paczula; Andrzej Wiecek; Grzegorz Piecha

doi:10.3390/ijms20030590

Cardiotonic Steroids-A Possible Link Between High-Salt Diet and Organ Damage

Int J Mol Sci. 2019 Jan 30;20(3):590. doi: 10.3390/ijms20030590.

Authors

Aneta Paczula¹, Andrzej Wiecek², Grzegorz Piecha³

Affiliations

¹ Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, Poland. paczula@poczta.onet.pl.
² Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, Poland. awiecek@sum.edu.pl.
³ Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20-24, 40-027 Katowice, Poland. g.piecha@outlook.com.

Abstract

High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ damage.

Keywords: fibrosis; hypertension; marinobufagenin; ouabain; salt.

Publication types

Review

MeSH terms

Animals
Blood Pressure / drug effects
Cardiac Glycosides / metabolism*
Humans
Hypertension / chemically induced
Hypertension / metabolism
Ouabain / pharmacology
Risk Factors
Sodium Chloride, Dietary / adverse effects*
Sodium-Potassium-Exchanging ATPase / metabolism

Substances

Cardiac Glycosides
Sodium Chloride, Dietary
Ouabain
Sodium-Potassium-Exchanging ATPase