This study was to investigate the prevalence and associated factors of inconsistent condom use with HIV-discordant regular male sex partners (RP: defined as their husband or steady boyfriends) in the last six months among HIV-infected women in China. We interviewed 256 HIV-infected women who currently had at least one HIV-discordant RP and had had sexual intercourse with such RP since diagnosis. The prevalence of inconsistent condom use with HIV-discordant RP was 48.4%. Associated factors included perceptions related to condom use and perceived competence in communicating with HIV-discordant RP regarding condom use.