Decreased 5-hydroxymethylcytosine immunoreactivity in primary Merkel cell carcinoma is a strong predictor for disease-specific death

Br J Dermatol. 2019 Aug;181(2):389-390. doi: 10.1111/bjd.17705. Epub 2019 Apr 23.

Authors

T Gambichler¹, K Schmitt¹, I Rüddel¹, M Dreibigacker¹, E Stockfleth¹, J C Becker²

Affiliations

¹ Skin Cancer Center, Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.
² Translational Skin Cancer Research, DKTK Partner Site Essen/Düsseldorf, German Cancer Consortium, Dermatology, University Duisburg-Essen, Essen, Germany.

PMID: 30703276
DOI: 10.1111/bjd.17705

No abstract available

Publication types

Letter

MeSH terms

5-Methylcytosine / analogs & derivatives*
5-Methylcytosine / analysis
5-Methylcytosine / metabolism
Aged
Aged, 80 and over
Biomarkers, Tumor / analysis
Biomarkers, Tumor / metabolism
Carcinoma, Merkel Cell / genetics
Carcinoma, Merkel Cell / mortality*
Carcinoma, Merkel Cell / pathology
Carcinoma, Merkel Cell / virology
DNA Methylation*
DNA-Binding Proteins / analysis
DNA-Binding Proteins / metabolism
Dioxygenases
Female
Follow-Up Studies
Humans
Immunohistochemistry
Isocitrate Dehydrogenase / analysis
Isocitrate Dehydrogenase / metabolism
Male
Merkel cell polyomavirus / isolation & purification
Neoplasm Recurrence, Local / diagnosis*
Neoplasm Recurrence, Local / epidemiology
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / virology
Neoplasm Staging
Pilot Projects
Prognosis
Proto-Oncogene Proteins / analysis
Proto-Oncogene Proteins / metabolism
Sex Factors
Skin / pathology
Skin Neoplasms / genetics
Skin Neoplasms / mortality*
Skin Neoplasms / pathology
Skin Neoplasms / virology
Viral Load

Substances

Biomarkers, Tumor
DNA-Binding Proteins
Proto-Oncogene Proteins
5-hydroxymethylcytosine
5-Methylcytosine
IDH2 protein, human
Isocitrate Dehydrogenase
Dioxygenases
TET2 protein, human