Breast involvement in mixed connective tissue disease

Ross Varma; Sandor Szilagyi; Manju Harshan

doi:10.1016/j.radcr.2019.01.001

Breast involvement in mixed connective tissue disease

Radiol Case Rep. 2019 Jan 17;14(4):430-435. doi: 10.1016/j.radcr.2019.01.001. eCollection 2019 Apr.

Authors

Ross Varma¹, Sandor Szilagyi², Manju Harshan³

Affiliations

¹ Department of Radiology, Mount Sinai West, 1000 Tenth Avenue, NY 10019, New York, USA.
² Department of Radiology, Mount Sinai Beth Israel, 10 Nathan D Perlman Pl, NY 10003, New York, USA.
³ Department of Pathology, Mount Sinai Downtown Union Square. 10 Union Square East, NY 10003, New York, USA.

Abstract

To date, mammographic involvement in mixed connective tissue disease has not been described in the literature to the authors' knowledge. In addition, only 2 case reports have described panniculitis in mixed connective tissue disease. We present a patient with mixed connective tissue disease with coarse sheet-like calcifications on mammography bilaterally, which increased over time corresponding to rise in levels of anti-dsDNA. Biopsy showed fat necrosis with calcifications, chronic inflammation and fibrosis, vasculitis, as well as CD3, CD4, and CD8+ T cells and CD20+ B cells. These findings are similar histologically and mammographically to "lupus mastitis."

Keywords: Lupus mastitis; MCTD; MCTD panniculitis; Mammography; Mastitis; Mixed connective tissue disease.

Publication types

Case Reports