Abstract
Four new C-geranyl flavonoids, paulownione D-G (1-4) were isolated from the 50% acetone-H2O extract of the flowers of Paulownia fortunei. The structures of the compounds were determined by extensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). All of the compounds (1-4) exhibited potent protection effects in H9c2 cardiocytes against the lipopolysaccharide (LPS)-induced inflammation.
Keywords:
C-geranyl flavonoids; Paulownia fortunei; anti-inflammatory activity.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Cell Line
-
Drug Evaluation, Preclinical
-
Flavonoids / chemistry*
-
Flavonoids / pharmacology*
-
Flowers / chemistry
-
Inflammation / chemically induced
-
Inflammation / drug therapy
-
Lamiales / chemistry*
-
Lipopolysaccharides / toxicity
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Myocytes, Cardiac / drug effects
-
Rats
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Flavonoids
-
Lipopolysaccharides